Dr. Alexandra King, MD, FRCPC, member of Nipissing First Nation and Cameco Chair in Indigenous Health and Wellness at the University of Saskatchewan, brings the conversation about knowledge synthesis full circle and takes podcast host Eugenia Eshkawkogan back to the beginning through an exploration of what is considered knowledge. This thoughtful conversation compels listeners to reflect on whether the approach used to understand knowledge makes sense, given the complexities of knowledge and the many ways of knowing and, importantly, the risk of relying solely on a single method. The theme of relationships runs throughout Eshkawkogan’s interview with Dr. King, from a consideration of our own relationship to knowledge and the assumptions we make about it, to the ways in which all research processes, including the approaches, ethics and designs, flow first from relationships at the individual level to relationships at the community level.